Dean Greyling and Wilhelm Steenkamp will not take any part in the Bulls game against the Stormers in Pretoria this Friday.
Greyling has a stress fracture to his foot and is out for the week, while Steenkamp is suffering from an AC joint injury and is out for two weeks.
With new Free State import Marcel van der Merwe only back in May after undergoing knee surgery, Bulls coach Frans Ludeke will in all likelihood go with Frik Kirsten at looshead prop when he names his side on Tuesday.
Dawie Steyn started training this week but will not be match fit yet.